The story follows Odysseus on his epic journey home after the Trojan War, highlighting his encounters with Polyphemus, the Sirens, and Circe, culminating in a heartfelt reunion with his wife, Penelope.

Four years after No Way Home, Peter lives alone, erased from the lives of those he loves. Fully devoted to protecting New York, mounting pressure triggers a physical evolution that threatens his existence as a powerful new threat emerges.